Nerve Blocks With Dexamethasone and Local Anaesthetic to Improve Postoperative Analgesia

• Status: Unknown status
• Trial end date: 2016-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Can the association of dexamethasone to the local anaesthetic in a single-shot femoral and sciatic nerve block improve analgesia postoperatively in patients submitted to total knee arthroplasty? Primary aim: Evaluate the efficacy of the association of dexamethasone to the local anaesthetic in a SSFNB and SSSNB in reducing pain scores, assessed by VAS.

Outcome measures: Mean pain scores in both groups. Secondary aims: Evaluate opioid consumption in the postoperative period (8- 12h, 24h, 48h) and assess incidence of side effects and complications (numbness, paraesthesias, weakness, site infection, haematoma and falls).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centro Hospitalar do Porto
• Treatments: Anesthetics; Anesthetics, Local; BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Ropivacaine

Criteria

Inclusion Criteria:

• Adult patients admitted foi unilaterla total knee arthroplasty

Exclusion Criteria:

• Refusal/Incapacity to give informed consent

• Contra-indication to general anesthesia

• Infection at needle insertion site

• Coagulation disorders

• Pre-existing neurologic disorders

• Known allergy to any of the drugs from the protocol

• ASA status >3

• Weight<50kg

• BMI>40

• Inability to understand or use VAS pain score