Neostigmine Treatment of Acute Pancreatitis Combined With Intra-abdominal Hypertension
Status:
Completed
Trial end date:
2018-05-30
Target enrollment:
Participant gender:
Summary
Acute pancreatitis(A) often complicated with Intra-abdominal Hypertension. After the onset of
acute pancreatitis, capillary leakage causing ascites,upper gastrointestinal tract
obstruction and paralytic ileus leading to an elevated IAP, severe IAH leads to ACS with high
mortality. Neostigmine is an anti-cholinesterase drugs, can enhance intestinal peristalsis,
promote flatus defecation. The aim of this study was to determine the effect of neostigmine
on reducing abdominal pressure and clinical prognosis in patients with AP by promoting
intestinal peristalsis and defecation.
Phase:
Phase 2
Details
Lead Sponsor:
The First Affiliated Hospital of Nanchang University