Neostigmine For Snoring During DISE

• Status: Terminated
• Trial end date: 2019-03-19
• Target enrollment: 0
• Participant gender: All

Summary

The study team is seeking a novel treatment for snoring involving local application of a nerve stimulant medication, neostigmine. In this study, neostigmine will be injected into 5 sites of the soft palate during a standard procedure, drug-induced sleep endoscopy, to evaluate the effect on snoring.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Emory University
• Treatments: Neostigmine

Criteria

Inclusion Criteria:

• Snoring or mild obstructive sleep apnea

• English-speaking

• Greater than 18 years old

• Able to give informed consent

Exclusion Criteria:

• On active anti-coagulation medication

• Pregnant women

• Hypersensitivity to neostigmine

• Peritonitis or mechanical obstruction of the intestinal or urinary tract

• Coronary artery disease

• Cardiac arrhythmia

• Recent acute coronary syndrome

• Myasthenia gravis