Overview

Neoadjuvant Nab-paclitaxel in Triple-negative or HER2-positive Breast Cancer

Status:
Recruiting
Trial end date:
2022-10-01
Target enrollment:
0
Participant gender:
Female
Summary
To evaluate the efficacy and safety of nab-paclitaxel combined with carboplatin for Chinese patients with triple-negative and HER2-positive breast cancer in the neoadjuvant setting.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Ruijin Hospital
Treatments:
Albumin-Bound Paclitaxel
Carboplatin
Paclitaxel
Trastuzumab
Criteria
Inclusion Criteria:

1. Written informed consent for all study according to local regulatory requirements
prior to beginning specific protocol procedures.

2. Age at diagnosis ≥ 18 years, female.

3. Histologically confirmed diagnosis of HER2-opsitive or triple-negative breast cancer.
ER/PR-negativity is defined as ≤1% stained cells; HER2-positivity is defined as IHC 3+
or in-situ hybridisation (ISH) ratio >2.0.

4. cT2-4NanyM0 or cTanyN1-3M0

5. ECOG ≤ 1, LVEF ≥ 55%.

6. Laboratory requirements: for hematology, absolute neutrophil count (ANC) ≥ 1.5 × 109 /
L and platelets ≥ 100 × 109 / L and hemoglobin ≥ 90 g/L; for hepatic function, total
bilirubin ≤ 1.5 × UNL, AST and ALT ≤ 2.5 × UNL; for renal function, SCr ≤ 1.5 × UNL

7. Patients must be available and compliant for treatment and follow-up.

Exclusion Criteria:

1. Prior chemotherapy, endocrine therapy or radiation therapy for any malignancy.

2. Known or suspected congestive heart failure (> NYHA I)

3. Currently active infection or severe symptomatic visceral disease.

4. Definite contraindications for the use of corticosteroids or known hypersensitivity
reaction to one of the compounds or incorporated substances used in this protocol

5. rior malignancy with a disease-free survival of < 5 years, except curatively treated
basalioma of the skin, pTis of the cervix uteri.

6. Participation in another clinical trial with any investigational, not marketed drug
within 30 days prior to study entry.

7. Pregnant or lactating patients. Patients of childbearing potential must implement
adequate non-hormonal contraceptive measures (barrier methods, intrauterine
contraceptive devices, sterilization) during study treatment.