Neoadjuvant Chemoradiation for Resectable Glioblastoma
Status:
Recruiting
Trial end date:
2023-12-31
Target enrollment:
Participant gender:
Summary
Preoperative therapy has not been well studied in resectable glioblastoma. This study
attempts to prospectively assess the feasibility and efficacy of preoperative chemo radiation
in improving local control, as this is the predominant mode of failure in these patients
leading to poor outcomes.
This Phase II study design would be used to proceed with the study treatment after meeting
pre-specified events in the initial phase, with goal being to determine whether the new
treatment paradigm is sufficiently promising to warrant a major controlled clinical
evaluation against the standard therapy.