NeoFent-I Study; Fentanyl Treatment in Newborn Infants; a Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Study
Status:
Completed
Trial end date:
2014-12-31
Target enrollment:
Participant gender:
Summary
The study will assess the efficacy of fentanyl using a pharmacokinetic/pharmacodynamic
(PK/PD) model where the concentration of the drug is related to effect curve (pain score
change in response to standardized procedural pain). Further cortical, physiological and
biochemical responses to fentanyl will be assessed, elucidating the feasibility before the
main study project (NeoOpioid) start.