NeoAdjuvant Chemotherapy Followed by Radical Hysterectomy (OP) Versus Primary Chemo-RADiation in Cervical Cancer FIGO Stage IB2 and IIB

• Status: Not yet recruiting
• Trial end date: 2025-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

Randomized comparison of neoadjuvant chemotherapy followed by radical hysterectomy with pelvic ± para-aortic lymphonodectomy (LNE) versus primary cisplatin-based chemo-radiation in patients with cervical cancer FIGO IB2 and IIB.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Charite University, Berlin, Germany
• Treatments: Albumin-Bound Paclitaxel; Carboplatin; Cisplatin; Ifosfamide; Isophosphamide mustard; Paclitaxel

Criteria

Inclusion Criteria:

• >18 years

• cervical cancer FIGO IB2, IIB,

• squamous cell, adeno or adenosquamous cell carcinoma

• informed consent

Exclusion Criteria:

• small cell/neuroendocrine component

• previous radiation, previous cancer

• pregnancy

• HIV

• severe co-morbidities