Nefopam vs Tramadol in the Prevention of Post Anaesthetic Shivering
Status:
Unknown status
Trial end date:
2019-06-01
Target enrollment:
Participant gender:
Summary
Post Anaesthetic Shivering is a common complication of Subarachnoid block. It is graded based
on it's severity and has been known to cause various problems like patient's discomfort,
hypoxia, change in hemodynamic variables of the patient and poor wound healing. This problem
has been managed via pharmacologic and non-pharmacologic means. Non-pharmacologic modalities
involve options aimed at warming the patient. Pharmacologically, opioids are used more
commonly to prevent and treat this condition. This then introduces the side effect of
nausea/vomiting and sedation which may reduce overall patient's satisfaction on the
perception of the Subarachnoid block. It is for this reason that Nefopam - a centrally acting
non-opioid, non-steroidal anti-inflammatory drug (NSAID) analgesic, relatively new drug in
the Nigerian market with significant anti-shivering effect is compared with a well
established opioid like Tramadol. Having similar cost profile, the option of replacing
Tramadol with Nefopam especially in conditions where the patient is more hemodynamically
unstable is considered in this project.