Nefopam Versus Ondansteron for Prevention of Post Spinal Shivering.
Status:
Recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
Spinal anesthesia affects the homeostatic systems resulting in intraoperative hypothermia and
subsequently shivering. In fact, shivering may be seen after this technique in 30 to 40% of
cases . Ondansetron and Nefopam have been used to prevent intraoperative shivering . However,
no prospective, randomized, double-blind study has been conducted to this date in order to
compare nefopam with ondansetron in the prevention of post-spinal anesthesia shivering.
The primary objective of this prospective, randomized, double-blind study is to compare the
incidence and intensity of shivering after spinal anesthesia for non-obstetric surgery in 2
groups of patients.
Group A: Patients receiving 8 mg of ondansetron diluted in 20 ml of 0.9% normal saline over
30 minutes as they arrive to the operating theater(75 patients).
• Group B: Patients receiving 20 mg of nefopam diluted in 20 ml of 0.9% normal saline over 30
minutes as they arrive to the operating theater (75 patients)