Overview

Nefopam Versus Ondansteron for Prevention of Post Spinal Shivering.

Status:
Recruiting

Trial end date:
2021-12-01

Target enrollment:
0

Participant gender:
All

Summary

Spinal anesthesia affects the homeostatic systems resulting in intraoperative hypothermia and subsequently shivering. In fact, shivering may be seen after this technique in 30 to 40% of cases . Ondansetron and Nefopam have been used to prevent intraoperative shivering . However, no prospective, randomized, double-blind study has been conducted to this date in order to compare nefopam with ondansetron in the prevention of post-spinal anesthesia shivering. The primary objective of this prospective, randomized, double-blind study is to compare the incidence and intensity of shivering after spinal anesthesia for non-obstetric surgery in 2 groups of patients. Group A: Patients receiving 8 mg of ondansetron diluted in 20 ml of 0.9% normal saline over 30 minutes as they arrive to the operating theater(75 patients). • Group B: Patients receiving 20 mg of nefopam diluted in 20 ml of 0.9% normal saline over 30 minutes as they arrive to the operating theater (75 patients)

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Saint-Joseph University

Treatments:

Nefopam
Ondansetron

Criteria

Inclusion Criteria:

- age between 18 and 65 years

- scheduled for a surgery under spinal anesthesia

Exclusion Criteria:

- pregnant or breastfeeding (for the women), if they are

- Allergy to any of the drugs to be used

- Long QT syndrome

- Hepatic insufficiency

- Renal failure

- Parkinson's disease

- Epilepsy

- Glaucoma

- Phenylketonuria