Nebulized Tranexamic Acid in Sinus Surgery

• Status: Recruiting
• Trial end date: 2021-12-25
• Target enrollment: 0
• Participant gender: All

Summary

The results of several recent studies on endoscopic sinus surgery through topical administration of tranexamic acid are encouraging in terms of the efficacy of tranexamic acid for intraoperative bleeding and other pathological conditions.The purpose of this study is to analyze the efficacy of nebulized tranexamic acid to improve the surgeon and patient experiences of sinus surgery and know the effective and safe dose of nebulized tranexamic acid.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Tranexamic Acid

Criteria

Inclusion Criteria:

• Either sexes (age 18-65 years) of ASA I-II who are listed for elective functional endoscopic sinus surgery (FESS) under general anesthesia

• normal accepted coagulation profile and hematocrit value ≥30

Exclusion Criteria:

• chronic renal failure

• liver cirrhosis

• bleeding disorders

• current anticoagulant therapy

• pregnancy or breastfeeding

• impaired color vision

• severe vascular ischemia

• history of venous thrombosis, pulmonary embolism

• long term treatment with acetylsalicylic acid or non-steroidal anti-inflammatory drugs not discontinued before surgery

• hemoglobin (HB) concentration <10 mg/dl _allergy to TXA.