Overview

Nebulized Heparin and Salbutamol in Mechanically Ventilated Patients With AECOPD

Status:
Completed
Trial end date:
2017-09-30
Target enrollment:
0
Participant gender:
All
Summary
This randomised study was designed to assess the efficacy of nebulised heparin and salbutamol in improving lung function in mechanically ventilated patients with AECOPD.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Ain Shams University
Treatments:
Albuterol
Calcium heparin
Heparin
Criteria
Inclusion Criteria:

- > or = 18 years of age,

- body weight 70-110Kg,

- height 160-180 cm

- with clinically evident AECOPD and in need for mechanical ventilation confirmed by
arterial blood gases (ABGs).

Exclusion Criteria:

- Excluded Patients from the study were those who were not enrolled within the first 24
hours of mechanical ventilation and those who were likely to be extubated within 24
hours. - History of ischemic heart disease,

- History of pulmonary bleeding within the previous 3 months,

- History of bleeding diathesis,

- Known to be allergic to heparin or

- History of thrombocytopenia after previous treatment with heparin.

- Female patients were excluded if they were pregnant or breast feeding.