Nebulized Bronchodilators and Cardiac Repolarization
Status:
Completed
Trial end date:
2013-12-31
Target enrollment:
Participant gender:
Summary
Patients of the ICU's often require bronchodilatory treatment due to bronchospasm caused by
conditions like : acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary
disease (COPD) or asthma. The β2 adrenergic drugs are one of the most commonly used for this
purpose. However it is known that they may cause tachycardia and may have substantial
proarrhythmic effect. The investigators' aim is to estimate the influence of nebulized
bronchodilatory drugs on selected electrophysiological parameters, whose changes are
generally recognized as potentially increasing the risk of ventricular and supraventricular
arrhythmias. Two drugs will be compared - salbutamol given in two doses and ipratropium
bromide