Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis

• Status: Completed
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a randomized, double-blind, controlled trial in the Pediatric Emergency Department. The primary objective is to determine whether nebulized 3% hypertonic saline is more effective than nebulized 0.9% saline in the treatment of bronchiolitis in the emergency department.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Texas Southwestern Medical Center

Criteria

Inclusion Criteria:

• Children 2-12 months of age presenting to Emergency Department

• Patients with a diagnosis of bronchiolitis defined as the first episode of wheezing and/or crackles in a child younger than 12 months who has physical findings of a viral respiratory infection and has no other explanation for the wheezing and/or crackles

• Patients with an RDAI score ≥ 6 as measured by a trained respiratory therapist

Exclusion Criteria:

• Previous history of wheezing

• Known heart or lung disease

• Premature birth defined as birth before 37 weeks gestation

• Immunosuppression or immunodeficiency

• Treatment with corticosteroids in the previous 48 hours

• Critically ill children - progressive respiratory failure requiring higher level of care, vital signs instability/need for emergency interventions to prevent clinical deterioration

• Oxygen saturation <85% on room air at the time of recruitment