Overview Nebivolol and the Endothelin (ET)-1 System Status: Completed Trial end date: 2016-12-01 Target enrollment: Participant gender: Summary The investigators hypothesize that nebivolol will reduce ET-1-mediated vasoconstrictor tone in adult humans with elevated blood pressure to a greater extent than either metoprolol or placebo. Phase: Phase 4 Details Lead Sponsor: University of Colorado, BoulderCollaborator: Forest LaboratoriesTreatments: AcetylcholineBQ 788cyclo(Trp-Asp-Pro-Val-Leu)MetoprololNebivololNitroprusside