Nebivolol and Endothelial Regulation of Fibrinolysis (NERF)
Status:
Completed
Trial end date:
2017-10-01
Target enrollment:
Participant gender:
Summary
The investigators hypothesize that nebivolol will improve endothelial t-PA release in adult
humans with elevated blood pressure to a greater extent than either metoprolol or placebo.
The investigators further hypothesize that the improvement in the capacity of the vascular
endothelium to release t-PA with nebivolol is mediated, in part, by the compound's
antioxidant properties.