Nebivolol Effect on Nitric Oxide Levels, Blood Pressure, and Renal Function in Kidney Transplant Patients
Status:
Completed
Trial end date:
2014-07-01
Target enrollment:
Participant gender:
Summary
This study will investigate the blood pressure lowering efficacy of nebivolol among renal
transplant recipients who are on calcineurin inhibitors which are believed to contribute to
hypertension by sympathetic nervous system (SNS) activation and decreased prostaglandin and
nitric oxide production. Hypotheses:
1. There is a significant difference in the effect of 12 months of Nebivolol versus
Metoprolol treatment on the plasma nitric oxide level of hypertensive renal transplant
patients.
2. There is a significant difference in the effect of 12 months of Nebivolol versus
Metoprolol treatment on the estimated glomerular filtration rate of hypertensive renal
transplant patients.
3. There is a significant difference in the effect of 12 months of Nebivolol versus
Metoprolol treatment on the systolic, diastolic and mean arterial blood pressures of
hypertensive renal transplant patients.