Near-infrared Fluorescence Imaging as a Supportive Tool for Localisation of Deep Infiltrating Endometriosis During Laparoscopy

• Status: Completed
• Trial end date: 2017-02-16
• Target enrollment: 0
• Participant gender: Female

Summary

The aim of the study is to establish a new and more accurate method to visualize the peritoneal changes caused by endometriosis using Indocyanine Green mediated fluorescence imaging. The hypothesis is that Indocyanine Green, a fluorescent dye that has wide applications throughout medicine in identifying vascularity of tissues and neovascularization, could facilitate the localization and excision of endometriotic lesions exploiting the hypervascularization due to the chronic inflammation

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Catholic University of the Sacred Heart

Criteria

Inclusion Criteria:

• Suspected endometriosis with necessity for laparoscopic confirmation and resection

• Regular menstrual cycles

Exclusion Criteria:

• Patients younger than 18 years and older than 50 years at time of operation

• Subject with previous history of adverse reaction or allergy to Indocyanine Green, iodine, shellfish or iodine dyes

• Documented allergy to sulfur containing compounds

• History of allergic reactions attributed to compounds of similar chemical or biologic composition to Indocyanine Green

• Subject has significant liver disease, cirrhosis or liver insufficiency with abnormal liver function tests (Total bilirubin increased by factor 1.5 than normal and/or serum glutamic oxaloacetic transaminase increased by factor 2 than normal)

• Subject has uremia, serum creatinine (> 2.0 mg/dl)

• Subject has severe coronary heart disease (instable angina pectoris)

• Pregnant or breast-feeding women

• Subject actively participating in another drug, biologic and/or device protocol

• The presence of medical conditions contraindicating general anesthesia or standard surgical approaches

• Subject has any medical condition, which in the judgment of the Investigator and/or designee makes the subject a poor candidate for the investigational procedure