Overview

Near Normalisation of BG Improves the Potentiating Effect of GLP-1

Status:
Completed
Trial end date:
2004-12-01
Target enrollment:
0
Participant gender:
All
Summary
The ability of glucagon-like peptide 1 to enhance beta-cell responsiveness to I.v. glucose is impaired in patients with type 2 diabetes mellitus compared with healthy individuals. We investigated whether 4 weeks of near-normalisation og blood glucose improves the potentiation of glucose-stimulated insulin secretion by GLP-1
Phase:
N/A
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Hvidovre University Hospital
Treatments:
Glucagon
Glucagon-Like Peptide 1
Criteria
Inclusion Criteria:

- Age 18-70 years

- Type 2 diabetes diagnosed after 30 years of age

- BMI > 25

Exclusion Criteria:

- Severe complications to diabetes

- Abnormal liver og kidney function

- Haemoglobin below the lower limit

- Macroalbuminuria

- Systemic disease

- Pregnancy