Natural History of Levodopa-Induced Dyskinesia (LID)
Status:
Withdrawn
Trial end date:
2020-12-01
Target enrollment:
Participant gender:
Summary
Levodopa is the main drug treatment for Parkinson's disease. Levodopa can cause unwanted and
uncontrolled movements called dyskinesias (LID). The severity of these movements can range
from subtle to extremely debilitating. These movements may or may not interfere with normal
activities such as putting on a coat or brushing ones teeth. Current estimates of the
occurrence rate of LID range from 12 % to 100% after one year of levodopa treatment. These
estimates used reporting mechanisms such as self-report and doctor-reported. These reporting
mechanisms are not reliable. We will use an objective measure of dyskinesia in the first 5
years of treatment for Parkinson's disease. The purpose of this protocol is to use an
objective measure to estimate dyskinesia onset.
Details
Lead Sponsor:
Oregon Health and Science University
Collaborator:
Oregon Clinical and Translational Research Institute