Natriuretic Peptide System as Therapy in Human Preclinical Left Ventricle Dysfunction
Status:
Completed
Trial end date:
2009-08-01
Target enrollment:
Participant gender:
Summary
In congestive heart failure, cardiac output is low, blood pressure is high, and the body
becomes congested with fluid. In normal people, when there is high blood pressure, the heart
muscle cells secrete a hormone that excretes sodium and water in the urine, reducing blood
pressure. The action of this hormone is called the natriuretic response. The purpose of this
study is to determine if nesiritide can improve an impaired natriuretic response in subjects
with asymptomatic systolic heart failure or asymptomatic diastolic heart failure.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
Horng Chen
Collaborators:
National Center for Research Resources (NCRR) National Heart, Lung, and Blood Institute (NHLBI)