Natriuretic Effect of Telmisartan Versus Placebo in Patients With Mild-to-Moderate Hypertension
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Study to compare the natriuretic effect of telmisartan to placebo in mild-to-moderate
hypertensive patients on a controlled sodium diet as well as to explore the effects of
telmisartan on norepinephrine, plasma renin activity (PRA), plasma aldosterone, urine
potassium, creatinin, chloride, bicarbonate and uric acid excretion. Additionally it was
assessed whether the natriuretic effect disappears after treatment when telmisartan is
stopped. The effects of telmisartan on seated clinic blood pressure and the relationship
between urine sodium loss and decrease in ambulatory blood pressure after the first dose were
assessed descriptively. Assessment of safety was also considered.