Nasal Inhalation of Pulmozyme in Patients With Cystic Fibrosis and Chronic Rhinosinusitis
Status:
Completed
Trial end date:
2009-02-01
Target enrollment:
Participant gender:
Summary
Rhinosinusitis disorders are often associated with Cystic Fibrosis. They can restrict quality
of life enormously and give cause to repeated ENT surgery. The basic defect in CF is a
dysfunction of chloride channels in exocrine glands, leading to retention of secretions and
consecutive chronic inflammation with bacterial superinfections.
The prospective placebo controlled cross-over study aims at the evaluation of a nasally
inhalation of Pulmozyme with respect to mucus retention and resulting inflammation.