Nasal Inhalation of Dornase Alfa (Pulmozyme) in Patients With Cystic Fibrosis and Chronic Rhinosinusitis
Status:
Completed
Trial end date:
2006-05-01
Target enrollment:
Participant gender:
Summary
Rhinosinusitis disorders are often associated with Cystic Fibrosis. They can restrict quality
of life enormously and give cause to repeated ENT surgery. The basic defect in CF is a
dysfunction of Chloride channels in exocrine glands, leading to retention of secretions and
consecutive chronic inflammation with bacterial superinfections.
The prospective placebo controlled cross-over study aims at the evaluation of the efficacy of
a nasally inhalation of Pulmozyme with respect to mucus retention and resulting inflammation.
Phase:
Phase 3
Details
Lead Sponsor:
University of Jena
Collaborators:
Dr. Gerlind Schneider PD Dr. Assen Koitschev, Tübingen PD Dr. Joachim Riethmöller, Tübingen