The purposes of this noninferiority randomized clinical trial are to:
1. determine whether the most commonly used commonly used non-narcotic analgesic (ibuprofen
600 mg + acetaminophen 325 mg) provides pain relief that is not unacceptably worse than
the most commonly prescribed narcotic containing analgesic (hydrocodone 5 mg. +
acetaminophen 325 mg, equivalent to Norco 5/325) in patients undergoing carpal tunnel
release.
2. Determine whether the following covariates affect pain level following surgery or
medication usage: gender, country (US/Canada), pre-operative CTS symptoms, site, workers
compensation status and employment status (employed/self-employed/unemployed-able to
work/unemployed-unable to work)
Phase:
Phase 4
Details
Lead Sponsor:
Horizon Health Network
Collaborators:
Carilion Clinic Jefferson Medical College of Thomas Jefferson University Lawson Health Research Institute McGill University Sanford Health Southern Illinois University University of Michigan University of Toronto University of Western Ontario, Canada
Treatments:
Acetaminophen Acetaminophen, hydrocodone drug combination Hydrocodone Ibuprofen Narcotics