Nandrolone Decanoate in the Treatment of Telomeropathies
Status:
Unknown status
Trial end date:
2017-02-01
Target enrollment:
Participant gender:
Summary
Decrease in blood cell counts due to deficient bone marrow function, called bone marrow
failure, as well as some lung diseases, called idiopathic pulmonary fibrosis, can be caused
by genetic defects in telomere biology genes, eventually causing telomere erosion. These
disorders are collectively termed "telomeropathies".
There is evidence that male hormones may improve blood cell counts in marrow failure, and
these hormones are able to stimulate telomerase function in hematopoietic cells in vitro. We
propose this study to the use of male hormone in patients with aplastic anemia and pulmonary
fibrosis associated with defects in telomeres.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
University of Sao Paulo
Collaborator:
Conselho Nacional de Desenvolvimento Científico e Tecnológico