Overview

Naltrexone in Treatment of Cocaine Dependence - 5

Status:
Completed
Trial end date:
1996-07-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to determine the efficacy of naltrexone in the treatment of cocaine dependence as measured by: 1) decreased urine benzoylecgonine (BE) levels, 2) decreased cocaine use by self-report, 3) decreased cocaine craving, and 4) retention in treatment.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
National Institute on Drug Abuse (NIDA)
Collaborator:
Cincinnati MDRU
Treatments:
Cocaine
Naltrexone
Criteria
Inclusion Criteria:

1. Meet DSM-III-R criteria for cocaine dependency,

2. 18 to 65 years of age,

3. capable of understanding the study,

4. voluntarily signed consent,

5. male or non-pregnant female using approved form of birth control.

Exclusion Criteria:

1. abnormal liver function tests (SGOT, SGPT, or GGT greater than twice the normal
values),

2. opioid use within the last 7 days,

3. use of neuroleptics,

4. having a severe acute medical problem,

5. unable to complete psychiatric rating scales, or

6. judged by the investigator to be unlikely to comply with the study protocol