Naltrexone & SSRI in Alcoholics With Depression/PTSD
Status:
Completed
Trial end date:
2015-07-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to evaluate the efficacy of naltrexone in combination with an
SSRI to reduce alcohol consumption in alcoholic patients with comorbid PTSD and depression.
We hypothesize that the combination of naltrexone and SSRI will exhibit a greater decrease in
alcohol consumption than that seen with treatment with SSRI alone, or with a combination of
another class of antidepressant and naltrexone. We also hypothesize that SSRI will be
effective in treating PTSD and depressive symptoms and naltrexone will be well tolerated.