Brain-dead patients who provide authorization for organ donation will be randomized to
naloxone or placebo if baseline arterial blood gas (ABG) after initiation of OPO (Organ
Procurement Organization) management reveals hypoxemia, as defined by the ratio of partial
pressure of oxygen in arterial blood (PaO2) to fraction of inspired oxygen (FiO2) below 300
mm Hg, unless they have already been ruled-out for lung recovery. Investigators aim to assess
whether naloxone improves oxygenation prior to organ recovery more than placebo.