Naloxone Nasal Spray Compared With Naloxone Injection for Opioid Overdoses Outside the Hospital
Status:
Completed
Trial end date:
2020-10-06
Target enrollment:
Participant gender:
Summary
This trial will compare the clinical response to intramuscular and intranasal naloxone in
pre-hospital opioid overdoses. Objective of the study is to measure and evaluate clinical
response (return of spontaneous respiration within 10 minutes of naloxone administration) to
a new nasal naloxone formulation in real opioid overdoses in the pre-hospital environment.
The aim is to demonstrate that intranasal administration of naloxone is not clinically
inferior to intramuscular administration, which is now standard treatment of care.