NOL Index to Compare the Intraoperative Analgesic Effect of Propofol Versus Sevoflurane

• Status: Recruiting
• Trial end date: 2022-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this prospective randomized controlled study is to compare the analgesic properties of propofol and sevoflurane using variation of the NOL index and standard monitoring (Heart Rate and Mean Arterial Blood Pressure) when patients under general anaesthesia with either agents are subjected to a standardized painful stimulus (a tetanic stimulation over the ulnar nerve at 70 mA, 100 Hz for 30 seconds).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ciusss de L'Est de l'Île de Montréal
• Treatments: Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• ASA status I, II or III

• Age 18 years or older

• Elective surgery under general anesthesia.

• Good understanding of English or French language

Non-inclusion Criteria

• Ongoing Coronary artery disease

• Patients with non-regular sinus cardiac rhythm, implanted pacemakers, prescribed antimuscarinic agents, α2-adrenergic agonists, β1-adrenergic antagonists and antiarrhythmic agents

• Emergent surgery

• Pregnancy/lactation

• Preoperative hemodynamic disturbance

• Central nervous system disorder (neurologic/head trauma/uncontrolled epileptic seizures)

• Patient refusal

• Drug or alcohol abuse within the last 6 months

• Chronic use of psychoactive drugs

• Pre-operative chronic opioid use or chronic pain, equivalent to oxycodone 20mg per oral, per day for more than 6 weeks

• History of psychiatric diseases or psychological problems

• Allergy or intolerance to any of the study drugs

Exclusion Criteria:

• Unexpected difficult airway requesting excessive, possibly painful airway manipulations.

• Intraoperative unexpected complications requiring strong hemodynamic support (transfusions, vasopressors, inotropes)