NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI

• Status: Not yet recruiting
• Trial end date: 2024-02-01
• Target enrollment: 0
• Participant gender: All

Summary

This project aims to evaluate the safety and efficacy of using a short-acting drug to reduce the maximal blood pressure during dangerous blood pressure spikes that happen during bowel care in individuals with spinal cord injury. the investigators will monitor the physiological effects of this drug during at-home bowel care to best understand the drug's effects in typical use.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Simon Fraser University
• Collaborator: University of British Columbia
• Treatments: Nitroglycerin

Criteria

Inclusion Criteria:

• participants must have had a traumatic spinal cord injury at least one year ago

• regular bowel care routine

• can communicate in English

Exclusion Criteria:

• cauda equina or conus lesions

• currently use ventilator

• colostomy, or do not perform regular bowel care

• skin breakdown (pressure sores)

• cannot communicate in English

• under 19 years old

• possibly or certainly pregnant

• medical/psychiatric condition or substance abuse that is likely to affect ability to complete study

• currently using medications containing PDE-5 inhibitors

• currently using medications containing GTN

• allergy to GTN