NICardipine Neuroprotection in AortiC Surgery (NICNACS)
Status:
Terminated
Trial end date:
2008-04-01
Target enrollment:
Participant gender:
Summary
Objective
The objective of this study is to discover whether an infusion of nicardipine is able to
reduce the time taken to achieve electrocerebral silence (ECS) during cardiopulmonary bypass
(CPB) for aortic surgery.
Hypothesis
By inhibiting cold-induced cerebral vasoconstriction, nicardipine will maintain cerebral
blood flow and allow more rapid cooling of the brain during CPB. This will manifest as a
reduction in the time taken to achieve ECS and also as a reduction in overall CPB time.