NEOadjuvant Chemotherapy Only Compared With Standard Treatment for Locally Advanced Rectal Cancer
Status:
Recruiting
Trial end date:
2024-12-31
Target enrollment:
Participant gender:
Summary
The main clinical hypothesis is that compared to radio-chemotherapy for low and mid rectal
tumors or surgery for high rectal tumors neoadjuvant chemotherapy reduces the rate of distant
relapse without increasing the rate of local relapse.
The aim of the present study is to compare long term and short term outcomes in rectal cancer
patients undergoing standard treatment (radio-chemotherapy/surgery) or experimental
neoadjuvant chemotherapy/surgery Furthermore, early surgical and medical complications, the
functional outcome, toxicity and quality of life (QoL) may be improved if radiotherapy can be
avoided.
Exploratory analyses are planned in order to find potential predictive markers for selecting
patients to either radio-chemotherapy/surgery or neoadjuvant combination
chemotherapy/surgery.