NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals
Status:
Recruiting
Trial end date:
2026-08-30
Target enrollment:
Participant gender:
Summary
Black individuals are more likely to have decreased insulin sensitivity which results in a
high risk for the development of cardiometabolic disease. The reasons for this are
incompletely understood. Natriuretic peptides (NPs) are hormones produced by the heart that
play a role in regulating the metabolic health of an individual. Low circulating level of NPs
is an important contributor to increased risk for diabetes. The NP levels are relatively
lower among Black individuals thus affecting their metabolic health and putting them at a
higher risk for diabetes. This study aims to test the hypothesis that by augmenting NP levels
using sacubitril/valsartan, among Black Individuals one can improve their metabolic health
(as measured by insulin sensitivity & energy expenditure) and help establish the role of NPs
in the underlying mechanism behind increased risk for cardiometabolic disease in these
population.