NAS Treatment - Opiate Versus Non-Opiate

• Status: Completed
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare two different medicines to treat babies with opiate withdrawal. The treatment medicines are morphine, which is an opiate, and clonidine, a non-opiate. Morphine is a narcotic medicine, with is included in most pain killers. Clonidine is another drug, but is different from morphine. It is also used for babies, and even adults for withdrawal symptoms. Both drugs are effective, but the purpose of this study is to see if one may be better than the other.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Henrietta Bada; University of Kentucky
• Treatments: Clonidine; Morphine

Criteria

Inclusion Criteria:

• Admitted to Neonatal Intensive Care Unit (NICU)- Gestational age (GA) >or= 35 wks

• Known prenatal opiate exposure (maternal history, positive opiate screen, positive neonatal urine or meconium screen)

• Symptomatic with Finnegan Neonatal Abstinence Scores meeting NICU protocol for treatment

Exclusion Criteria:

• Seizures

• Major congenital malformations

• Unlikely to survive

• Parents not able to understand English