Oxidative stress has been investigated as a key factor in the pathogenesis and progression of
endometrioma. High follicular fluid ROS levels and serum can be related to negative IVF/ICSI
outcomes in infertile women with endometrioma. Therefore, the use of antioxidants such as
N-acetyl cysteine (NAC) may be reduced complications of endometrioma. To study this
hypothesis, we designed a double-blind, randomized clinical trial study that aimed to
determine the effect of N-acetyl cysteine (NAC) on stress oxidative factors and pregnancy
outcomes in IVF/ICSI cycles in endometrioma patients.