N2007-02:Bevacizumab,Cyclophosphamide,& Zoledronic Acid in Patients W/ Recurrent or Refractory High-Risk Neuroblastoma
Status:
Completed
Trial end date:
2019-12-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different
ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and
help kill them or carry tumor-killing substances to them. Drugs used in chemotherapy, such as
cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing
the cells or by stopping them from dividing. Zoledronic acid may stop the growth of tumor
cells in bone. Giving bevacizumab together with cyclophosphamide and zoledronic acid may kill
more tumor cells.
PURPOSE: This phase I trial is studying the side effects of giving bevacizumab together with
cyclophosphamide and zoledronic acid in treating patients with recurrent or refractory
high-risk neuroblastoma.
Phase:
Phase 1
Details
Lead Sponsor:
New Approaches to Neuroblastoma Therapy Consortium