N-acetylcysteine in the Treatment of PTSD and Addiction

• Status: Completed
• Trial end date: 2014-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Examine the effects of N-acetylcysteine on PTSD symptoms, craving and substance use in veterans with PTSD and comorbid substance use disorders.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical University of South Carolina
• Treatments: Acetylcysteine; N-monoacetylcystine

Criteria

Inclusion Criteria:

• 18-65 year old

• U.S. military Veteran, Reservist, or National Guard member

• DSM-IV diagnostic criteria for current (past 6 months) SUD and PTSD or subthreshold PTSD (i.e., met criteria for cluster B (re-experiencing) and either cluster C (avoidance) or D (hyperarousal), as well as duration of one month and clinically significant impairment)

• Score of > 21 on the Mini-Mental State Exam (MMSE).

Exclusion Criteria:

• Unstable medical conditions

• Bipolar or psychotic disorders

• Seizures or asthma

• Prior treatment with NAC

• Suicidality

• Enrolled in ongoing PTSD treatment (pharmacotherapy or psychosocial)

• Females: could not be pregnant or lactating