N-acetylcysteine in Alcohol Dependence

• Status: Completed
• Trial end date: 2009-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The present study is designed to find out if N-acetylcysteine works in reducing alcohol drinking and craving.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Minneapolis Veterans Affairs Medical Center
• Collaborator: Minnesota Veterans Medical Research and Education Foundation
• Treatments: Acetylcysteine; N-monoacetylcystine

Criteria

Inclusion Criteria:

• age 18 - 65

• alcohol dependence by DSM-IV

• heavy drinking at least 4 times in the past month

• able to provide informed consent

Exclusion Criteria:

• current drug abuse or dependence by DSM-IV criteria (except nicotine or cannabis)

• current psychotic disorders, bipolar disorders, or cognitive disorders

• current suicidal or homicidal ideation

• positive illicit drug screen (except cannabis)

• Clinical Institute Withdrawal Assessment for Alcohol, Revised >15

• initiation of individual therapy or counseling in the past 3 months

• changes in doses of psychiatric medications in the past 3 months

• clinically unstable cardiac, hepatic, renal, neurologic, or pulmonary disease

• current use of naltrexone, disulfiram or acamprosate

• pregnant or nursing women, or inadequate birth control methods in women of childbearing potential