N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media
Status:
Withdrawn
Trial end date:
2019-11-29
Target enrollment:
Participant gender:
Summary
Chronic suppurative otitis media (CSOM) can be particularly difficult to treat as a number of
patients do not respond to routine antibiotic or surgical treatments. The current treatment
involves administering combination antibiotic anti-inflammatory ear drops such as Ciprodex
(ciprofloxacin 0.3% / dexamethasone 0.1%). Although most patients experience a relief of
symptoms, a fraction of patients remain refractory to treatment. Recent findings suggest that
the addition of N-acetylcysteine (0.5-2%) to Ciprodex is a superior treatment for otitis
media with effusion compared to the use of Ciprodex alone.