N-Acetyl Cysteine Protects Pulpal Stem Cells in Endodontic Revascularization
Status:
Unknown status
Trial end date:
2020-06-15
Target enrollment:
Participant gender:
Summary
Pulp re-vascularization/regeneration is a procedure performed to allow pulpal stem cells to
survive and/or differentiate to allow immature tooth root structures to grow to full
maturity. Currently, the procedure includes disinfection of the necrotic root canal space and
induction of bleeding to potentiate pulpal stem cell differentiation to allow root growth on
an immature root. A number of studies conducted previously demonstrate that N-acetyl cysteine
(NAC) potentiates differentiation of pulpal stem/stromal cells and protects pulpal cells from
apoptosis. 14-18 human subjects will be recruited forming two groups where pulp
re-vascularization/regeneration procedures will be performed with or without the use of NAC
treatment prior to induction of bleeding. Recall follow-up appointments will be done at 6
months and 1 year post treatment with subsequent yearly appointments until full root growth
has been achieved.