Myocardial Protection With Adenosine During Primary Percutaneous Coronary Intervention in Pts With STEMI

• Status: Completed
• Trial end date: 2012-07-01
• Target enrollment: 0
• Participant gender: All

Summary

OBJECTIVE: to evaluate the safety and efficacy of a brief intracoronary infusion of ADO applied at the time of reperfusion to limit infarct size and LV remodelling in patients with ACSST submitted to primary ACTP.

DESIGN: Multicentric, prospective, randomised, parallel, placebo-controlled double-blind study.

PATIENTS: 200 patients older than 18 with ACSST and without prior myocardial infarction receiving primary PTCA within 6 hours after symptom onset.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: David Garcia-Dorado
• Collaborators: Hospital Clínico Universitario de Valladolid; Hospital General Universitario Gregorio Marañon; Hospital Universitario Virgen Macarena; Instituto de Ciencias del Corazon
• Treatments: Adenosine

Criteria

Inclusion Criteria:

• patients older than 18 years.

• patients with acute coronary syndrome with ST segment elevation within six hours of the onset of symptoms.

Exclusion Criteria:

• patients younger than 18 years and pregnant women.

• patients with previous transmural infarction.

• patients with clinical evidence of bronchospastic lung disease or prior bronchodilator therapy.

• patients with pacemakers.

• patients with TIMI flow higher than 1 and lower than 3.