Myocardial Fibrosis Progression in Duchenne and Becker Muscular Dystrophy - ACE Inhibitor Therapy Trial

• Status: Completed
• Trial end date: 2013-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This trial intends to evaluate myocardial Fibrosis progression in Duchenne and Becker Muscular Dystrophy, as well the influence of ACE inhibitors in fibrosis progression. Additionally, this study aims to determine genetic predictors of cardiac involvement in these dystrophies.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: InCor Heart Institute
• Collaborators: Federal University of Minas Gerais; University of Sao Paulo
• Treatments: Angiotensin-Converting Enzyme Inhibitors; Enalapril; Enalaprilat

Criteria

Inclusion Criteria:

• Patients with biopsy-proven Muscular Dystrophy of Duchenne or Becker

Exclusion Criteria:

• Contraindications to cardiovascular magnetic resonance imaging