Myo-inositol Versus Metformin in Obese Women With Polycystic Ovary Syndrome
Status:
Completed
Trial end date:
2012-12-01
Target enrollment:
Participant gender:
Summary
The aim of this study is to compare the effects of six months treatment of two
insulin-lowering therapies on the clinical and endocrine-metabolic parameters in obese women
affected by polycystic ovary syndrome. The study group includes 40 patients, randomly
allocated to subgroup A (metformin 1500 mg/day) and subgroup B (myo-inositol 1500 mg/day).
The investigations include menstrual pattern and hirsutism score evaluation, hormonal assays,
oral glucose tolerance test, euglycemic hyperinsulinaemic clamp and lipid profile at baseline
and after six months of treatment.