Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers
Status:
Completed
Trial end date:
2018-07-01
Target enrollment:
Participant gender:
Summary
Mycotic Antimicrobial Localized Injection (MALIN) is a randomized, masked, two-arm clinical
trial investigating intrastromal voriconazole in the treatment of fungal corneal ulcers.
There is currently little evidence to guide the treatment of fungal keratitis beyond topical
anti-fungal drops, though intrastromal voriconazole and oral antifungal treatments are used
as well. This study will provide evidence to guide the treatment of fungal keratitis in the
future. The purpose of this study is to determine differences in microbiological cure for
3-day repeat cultures between different antifungal treatments. For this study, there will be
1:1 randomization to one of these two treatment groups: 1) topical natamycin plus
intrastromal voriconazole injection or 2) topical natamycin alone.