Muscle Strain in Multiple Sclerosis Patients Measured by Ultrasound Speckle Tracking Technique
Status:
Recruiting
Trial end date:
2022-02-01
Target enrollment:
Participant gender:
Summary
Despite effective treatments, the majority of patients with multiple sclerosis experience
walking impairments to a degree where walking aids or a wheelchair is required. Since 2009,
medical treatment of walking impairments has been possible with fampridine, which has proven
effective in approximately 40% of the patients. At present, the treatment is offered on the
basis of a measurable improved walking function evaluated by simple performance-based walking
tests. The treatment is offered on the basis of a measurable improved walking distance.
This is shown today using simple performance-based walking tests that are difficult to
complete for those MS patients who are without gait function but could still benefit from
fampridine treatment.
Ultrasound speckle tracking is a non-invasive ultrasound technique, with the potential to
measure muscle function, including muscle contractility (through strain). Ultrasound speckle
tracking is designed for dynamic cardiac muscular examination, but can in a modified version
be used for assessment of the skeletal muscles.
The purpose of this project is to use ultrasound speckle tracking to monitor muscle
contractility in MS patients receiving vs. not receiving fampridine treatment. Furthermore,
to relate these results to biomarkers in blood and urine to examine disease progression and
muscle activity.
Phase:
N/A
Details
Lead Sponsor:
University of Southern Denmark
Collaborators:
Fonden for scleroseramte på Fyn Fonden for scleroseramte paa Fyn Fonden til Lægevidenskabens Fremme Lounkær Fonden Odense University Hospital Overlægeråds forskningsfond Region of Southern Denmark Sygehus Lillebaelt TH MAIGAARDS EFTF. FRU LILY BENTHINE LUNDS FOND AF 1. JUNI 1978 The Augustinus Foundation, Denmark. The Danish Multiple Sclerosis Society The Lily Benthine Lunds Foundation The Lounkaer Foundation University of Miami