Multiple Ascending Dose Study of TRN-157 in Stable Mild and Moderate Asthmatics

• Status: Completed
• Trial end date: 2016-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This multiple ascending dose study is to determine the safety and bronchodilator activity of TRN-157 in 59 mild and moderate asthmatics.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Theron Pharmaceuticals, Inc.
• Treatments: Tiotropium Bromide

Criteria

Inclusion Criteria:

Patients who meet the following criteria will be considered eligible to participate in the study:

• The patient is ≥ 18 and < 70 years of age, and gives informed consent

• Clinical diagnosis of mild to moderate asthma of at least 6 months duration and age of onset < 50 years

• Presently using ICS at moderate doses (equivalent to 200-800 µg of budesonide or 88-500 µg of fluticasone daily)

• ≥ 12% and ≥ 200 mL improvement in FEV1 to 4 puffs albuterol by metered-dose inhaler (MDI) at screening visit

• Patient is willing to use acceptable form of birth control during trial and for one month thereafter

• Ability to measure morning (AM) peak expiratory flow (PEF) on schedule using electronic peak flow meter (EPFM) and to complete the study diary correctly at least 70% of the time during the run-in period

• After 7 day withdrawal from LABA therapy and overnight withdrawal from SABA therapy (except rescue medication), patient has between 55% - 80% of predicted FEV1 at CV2

Exclusion Criteria:

A patient meeting any of the following criteria is not eligible for enrollment in the study:

• A clinical diagnosis of chronic obstructive pulmonary disease (COPD), chronic bronchitis, bronchiectasis, or other significant pulmonary disease other than asthma

• History of upper or lower respiratory infection within 4 weeks of screening

• History of asthma exacerbation requiring oral or systemic corticosteroids or hospital admission within 6 months of screening

• History of myocardial infarction, or cardiac conduction abnormalities, including but not limited to atrial fibrillation, and paroxysmal atrial tachycardia

• Hospitalization due to cardiac failure within the last 6 months

• History of narrow angle glaucoma or obstructive uropathy

• Current smokers or vapers, or former smokers with > 10 pack-year (self-reported) history of smoking

• Patients who presently use the following medications will not be eligible for participation:

• Long-acting muscarinic receptor antagonist (LAMA)

• LABA (but may be withdrawn and converted to SABA x 7 days prior to entry)

• Leukotriene pathway blockers

• Anti-IgE antibody (Xolair) within last 6 months prior to CV1

• Phosphodiesterase 4 (PDE4) inhibitors (e.g., Roflumilast)

• Cromolyn

• Methylxanthines (e.g., aminophylline and theophylline)

• 5-Lipoxygenase inhibitor (e.g., Zileuton)

• Allergies to LAMA therapies

• History of life-threatening asthma exacerbation requiring ICU admission, mechanical ventilation, or tracheostomy