Multiparametric MRI Study of Endogenous Analgesia and Prediction the Efficacy of Migraine Pharmacological Prevention

• Status: Completed
• Trial end date: 2017-11-06
• Target enrollment: 0
• Participant gender: Female

Summary

To delineate brain mechanisms that subserve EA in the healthy state and to identify alterations in mechanisms supporting EA in chronic pain and their therapeutic relevance. Individuals with migraine will be examined between episodes in order to assess basal alterations in the efficiency of spatial and temporal filtering of noxious information. This population provides the unique opportunity to examine such processes without confounds arising from ongoing pain.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: d_yarnitsky
• Treatments: Duloxetine Hydrochloride

Criteria

Inclusion Criteria:

• patients diagnosed with migraine based on the International Headache Society (IHS) criteria 1 that have >4 attacks/month, both with and without aura

Exclusion Criteria:

• patients receiving any migraine preventive treatment during last 3 months or prior treatment with amytriptiline

• other chronic pain conditions

• psychiatric, other neurological diseases, language barrier or cognitive dysfunction