Multiomics After Headache Provocation of People Who Are Unable to Have Headache
Status:
Completed
Trial end date:
2020-03-12
Target enrollment:
Participant gender:
Summary
Headaches are extremely common illnesses with a combined lifetime prevalence of 90-99% in
Europe. Despite this high prevalence, there are persons who have never, in their whole life,
encountered a headache.
The aim of the study is to identify factors that protect against headache by studying
multiomics in people who never have had a headache (headache resistant) versus non-resistant
controls.
The investigators will measure multiomic changes (transcriptomics and metabolomics) after
headache provocation with isosorbide mononitrate. 3 blood samples, two for RNA and one for
metabolomics are taken right before administration of isosorbide mononitrate, 3 hours after
administration of isosorbide mononitrate and again 5 hours after administration of isosorbide
mononitrate.
The investigators hope to contribute with novelty to the current understanding of headache
pathophysiology and development of more efficient treatment of headache.