Multimodal Versus Opioid aNalgesia in carDiAc Surgery

• Status: Recruiting
• Trial end date: 2022-06-30
• Target enrollment: 0
• Participant gender: All

Summary

To compare standard "Fentanyl - Tramadol - Paracetamol - Oxycodone" regimen to a multimodal painmanagement "pregabalin- minimal fentanyl-ketamine-lidocain-dexmedetomidine- paracetamol" to determine which therapy provides the most comfort, the fastest extubation time, the least pain and the least delirium.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital, Ghent
• Treatments: Dexmedetomidine; Ketamine; Lidocaine; Magnesium Sulfate; Pregabalin

Criteria

Inclusion Criteria:

• Patients undergoing first time cardiac surgery by median sternotomy

• Elective surgery or semi-urgent: there needs to be time to provide 1 hour before surgery the intake of pregabalin

• ≥ 18 years for men

• Women who are in menopause

• Possibility to communicate with the patient to score pain and comfort

• Signed Informed Consent, signed by subject able and willing to provide written informed consent for study participation

Exclusion Criteria:

• Urgent surgery

• Women who are in premenopause

• Hypersensitivity to any of the study medication

• In case of direct postoperative revision the patient is NOT excluded.